How do you think Damascus will be destroyed and when? Prior to Daniel’s 70 week? And will it be by a nuke from Israel or will 100 to 300 metric tons of biological and chemical weapons stored in Syria contaminate their own city?
The Bible does not state this specifically, but I believe Isaiah 17, the destruction of Damascus, will be fulfilled before Daniel’s 70th Week begins. I say this because I believe the battle of Ezekiel 38 ushers in Daniel’s 70th Week and there’s no mention of Syria participating in that battle. Since Syria has been such a prominent adversary of Israel I’ve concluded the reason for the omission is that Damascus will have already been destroyed.
As for how this destruction will take place, the Bible is similarly unspecific. All it says is that Damascus will no longer be a city but will become a heap of ruins (Isaiah 17:1). Recently there’s been some speculation that Israel will level the city in the process of destroying Syria’s stockpile of biological and chemical weapons to prevent them from falling into the hands of terrorists. Unless these weapons are randomly scattered in storage facilities throughout Damascus that seems a bit far fetched to me. Israel has very precise demolition capabilities and would not wipe out such a large civilian population center without extreme provocation. Also I think Isaiah 17 hints that Israel’s actions will be retaliatory, not preemptive.